Tumor Treating Fields: Adjuvant Treatment for High-grade Gliomas
نویسندگان
چکیده
منابع مشابه
Medical Research Council adjuvant trial in high-grade gliomas.
Working Party has reported a phase III comparative trial of radiother-apy with adjuvant versus no adjuvant chemotherapy with procarbazine, lomustine, and vincristine (PCV) in patients with high-grade gliomas. 1 At the time of study design, PCV was considered to be potentially the best standard of care, although the superiority of this regimen over single-agent nitrosourea has recently been ques...
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The 2-year survival rate of patients with glioblastoma accrued to research studies increased from 10% to nearly 40% from 2000 to 2010. These improvements began with the demonstration of a survival benefit when daily temozolomide was administered with 6 weeks of standard radiation and for 6 months thereafter. This treatment regimen is often associated with significant lymphopenia, thrombocytopen...
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PURPOSE OF REVIEW Although therapies for patients with recurrent high-grade gliomas are limited, there has been important progress recently. This review summarizes current treatments for recurrent high-grade gliomas with an emphasis on more novel approaches. RECENT FINDINGS There is increasing evidence that antiangiogenic therapies have activity in high-grade gliomas. Recently, the United Sta...
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AIMS Relapsed high-grade gliomas (HGGs) have poor prognoses and there is no standard treatment. HGGs have ischemia/hypoxia associated and, as such, drugs and oxygen have low access, with increased resistance to chemotherapy and radiotherapy. Tumor hypoxia modification can improve outcomes and overall survival in some patients with these tumors. In previous works, we have described that cervical...
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BACKGROUND We investigated the efficacy of the Wee1 inhibitor MK-1775 in combination with radiation for the treatment of pediatric high-grade gliomas (HGGs), including diffuse intrinsic pontine gliomas (DIPGs). METHODS Gene expression analysis was performed for 38 primary pediatric gliomas (3 grade I, 10 grade II, 11 grade III, 14 grade IV) and 8 normal brain samples using the Agilent 4 × 44 ...
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ژورنال
عنوان ژورنال: Seminars in Oncology Nursing
سال: 2018
ISSN: 0749-2081
DOI: 10.1016/j.soncn.2018.10.007